Yes we would say that the third week of the preseason is very much a dress rehearsal for the regular season. Joe Duffy's Picks goes 2-0 with Wise Guy plays on the Jets and Eagles-Jaguars OVER.

Today Joe Duffy's Picks has the Minnesota Vikings (+3) to San Francisco 49ers. The 49ers definitely sound like this is more of an opening preseason game than the so-called, "dress rehearsal."

Colin Kaepernick is only expected to play briefly at QB to give four stiff battling for the backup signal-calling job. Seneca Wallace has not played in the NFL since the 2010 season, yet may be the backup. Scott Tolzien, Colt McCoy, rookie B.J. Daniels, the mistake machine in college are expected to get most of the playing time. They make Jacksonville's QBs sound good.

It does not look like San Francisco is playing too many key players much. Frank Gore, who had two carries Aug. 16 at Kansas City, should get a similar workload against the Vikings, Harbaugh said.

Vikings superstar Adrian Peterson is likely to make his preseason debut tonight. All indications are that Minnesota will take this game a bit more seriously. We look for them to win it outright.

Today Joe Duffy's Picks get the Saints-Texans side from the NFL Specialist. Oh the excitement for football regular season beginning next Thursday.

We are 5-2 the last two days with all Wise Guys. In addition to the NFL Major side get four MLB winning picks, two of them are Wise Guys.