Wise Guy
(NFL) San Francisco vs. Seattle,
Point Spread: -3.50 | -105.00 Seattle (Home)
Result: Win
Colin Kaepernick 1-2 straight up straight up as a starter vs Seattle, compared to 20-5 vs all other teams. That is because Seattle is the only team with the talent and schemes to slow him down without blitzing. Kaepernick is the most blitzed quarterback in the NFL since 2012.

Not versus Seattle, who use 4-man rush. Against the Seahawks, Kaepernick has completed 49.3 percent of his passes against a standard pass rush but 64.4 versus rest of the league.

Seattle is the most incredible team at home in the NFL. Seattle, the No. 1 defense in the NFL this season, has not allowed more than 19 points in any of its past six games, averaging only 11.2 points per game over that stretch. The Seahawks outscored the 49ers 71-16 in the last two games in Seattle.