While both teams have new HC's only one team is trying to change the culture of their program. Former 49ers player and now GM John Lynch and HC Kyle Sanahan have talked about a complete attitude overhaul and in this first home game for the new regime I believe they will go all out. Shanahan is also the OC and after putting up 434 yards at KC his QB's have clearly grasped his offense. Denver playing a second straight road game and while they won 24-14 LW they were outgained by 82 yards (363-281) and benefitted from a +2 turnover edge.
Take the 49ers here at home.