These two met twice last season, both games won by LSU straight up, though they split against the spread. Neither side had grueling non-conference schedules nor has faced a ranked opponent to this point.
Vanderbilt defense ranks 14th in the SEC in allowing opponents to shoot 41.4% against them, an area that LSU has to take advantage of. The Tiger can also can an edge on the boards in this matchup and their defense is third in the SEC, keeping teams to 37.7% shooting. LSU is 9-0 SU and 5-4 ATS at home this season.

Take the Tigers to cover.