While these two teams may be travelling in different directions in the standings, we aren't sold on the Bills as a good football team just yet. The Bills are on a three-game winning streak, which is their first such streak since 2011. They have not won four games in a row since they started 4-0 eight years ago in 2008. The Bills are at their best when they are running the football, and when teams run the ball that means the clock keeps ticking. We expect this to be a prime let down spot for Rex Ryan's team and given the fact that we are no longer putting our money on Blaine Gabbert, this is a spot where we like the Niners. Colin Kaepernick will be under center and protests aside, he should be rested and ready to make the most of what is certainly his last opportunity to be a starting QB in the NFL. He will be going up against a defense that is likely to be missing DT Marcell Dareus once again, who is nursing a hamstring issue. Look for a lower scoring game, where this many points is way too many to be giving up. San Francisco is 4-2 SU in its last six games against Buffalo with the most recent win coming in 2012 by a 45-3 score.